Analytical considerations for longitudinal analysis of eGFR in patients after lung transplantation

Glomerular filtration rate (GFR) is measure of how well the kidneys filter the blood by removing waste and extra water to make urine. GFR is used to help diagnose kidney disease at an early stage, to monitor people with chronic kidney disease (CKD), to monitor people with other conditions that cause kidney damage, such as diabetes and high blood pressure. Often treatment interventions may result in an initial acute effect on eGFR shortly after the treatment that differs from the long-term treatment effect. When this occurs, the rate of decline in eGFR over time may be characterized by two slopes: an acute slope and chronic slope. In this study, we present longitudinal data modeling strategies characterizing the rate of decline in eGFR among individuals with AKI and CKD in a large cohort of lung transplant recipients.

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Women in Statistics and Data Science 2024