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Application of Analysis Methods for Vaccine Efficacy in a Dengue Trial

Abstract Number:

1673 

Submission Type:

Contributed Abstract 

Contributed Abstract Type:

Poster 

Participants:

Jung-Jin Lee (1), Tulin Shekar (2)

Institutions:

(1) Merck, N/A, (2) Merck & Co., Inc., N/A

Co-Author:

Tulin Shekar  
Merck & Co., Inc.

First Author:

Jung-Jin Lee  
Merck

Presenting Author:

Jung-Jin Lee  
Merck

Abstract Text:

The vaccine efficacy is defined as the reduction of relative risk of disease 1-(Rv/Rp), with Rv and Rp as the incidence rates for the disease of interest in the vaccine and placebo groups, respectively. A conditional exact method proposed by Chan and Bohidar (1998) is often used to estimate the vaccine efficacy and its confidence interval. In this poster, we will compare the conditional exact method with two alternative approaches: Poisson regression and modified Poisson regression proposed by Zou (2004) by using trial data with and without follow-up time adjustment. Dengue epidemiologic distribution across Brazil will be provided via a QR code.

Keywords:

Vaccine efficacy|conditional exact method|Poisson regression|modified Poisson regression| |

Sponsors:

Biometrics Section

Tracks:

Miscellaneous

Can this be considered for alternate subtype?

No

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I have read and understand that JSM participants must abide by the Participant Guidelines.

Yes

I understand that JSM participants must register and pay the appropriate registration fee by June 1, 2024. The registration fee is non-refundable.

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