Abstract Number:
1673
Submission Type:
Contributed Abstract
Contributed Abstract Type:
Poster
Participants:
Jung-Jin Lee (1), Tulin Shekar (2)
Institutions:
(1) Merck, N/A, (2) Merck & Co., Inc., N/A
Co-Author:
First Author:
Presenting Author:
Abstract Text:
The vaccine efficacy is defined as the reduction of relative risk of disease 1-(Rv/Rp), with Rv and Rp as the incidence rates for the disease of interest in the vaccine and placebo groups, respectively. A conditional exact method proposed by Chan and Bohidar (1998) is often used to estimate the vaccine efficacy and its confidence interval. In this poster, we will compare the conditional exact method with two alternative approaches: Poisson regression and modified Poisson regression proposed by Zou (2004) by using trial data with and without follow-up time adjustment. Dengue epidemiologic distribution across Brazil will be provided via a QR code.
Keywords:
Vaccine efficacy|conditional exact method|Poisson regression|modified Poisson regression| |
Sponsors:
Biometrics Section
Tracks:
Miscellaneous
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