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Analysis Case Study: Alpha Spending Approach Applied to Propensity Score Matched Observational Study

Abstract Number:

2557 

Submission Type:

Contributed Abstract 

Contributed Abstract Type:

Speed 

Participants:

Derek Blankenship (1), Quentin Eloise (1)

Institutions:

(1) Fresenius Medical Care, N/A

Co-Author:

Quentin Eloise  
Fresenius Medical Care

First Author:

Derek Blankenship  
Fresenius Medical Care

Presenting Author:

Derek Blankenship  
Fresenius Medical Care North America

Abstract Text:

Alpha spending approaches (ASAs) for randomized controlled trials (RCTs) control type I errors of interim analyses aimed to shorten study duration. Propensity score matching (PSM) in observational settings mimic RCTs to limit biases but can remain lengthy. The purpose of this project is to apply ASAs to a PSM study and evaluate results.
Blankenship (2022) published a 2-year PSM study assessing dialysis patients attending a Transition Care Units (TCU). They reported TCU patients had higher rates of transplant referral (TR) and preferred modality compared to controls and no difference in mortality and hospitalizations (α=0.05).
This project divided the study into 8 quarters consisting of the patients and outcome information available at each look. PSM and statistical methods were performed as in the published analysis while applying ASAs.
ASAs determined modality and TR were significant at look 2, hospitalization was never significant, and mortality was significant at look 1 and 4. Modality and TR results could have been determined at 6 months, while mortality was inconsistent over time. Further research would inform if and how to apply ASAs to observational studies.

Keywords:

Alpha spending function|Observational study|Real world evidence|Propensity score matching|Longitudinal analysis|Group sequential design

Sponsors:

Health Policy Statistics Section

Tracks:

Miscellaneous

Can this be considered for alternate subtype?

Yes

Are you interested in volunteering to serve as a session chair?

Yes

I have read and understand that JSM participants must abide by the Participant Guidelines.

Yes

I understand that JSM participants must register and pay the appropriate registration fee by June 1, 2024. The registration fee is non-refundable.

I understand