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Implementing weighted interval censoring survival analysis on tobacco regulatory science

Abstract Number:

3010

Submission Type:

Contributed Abstract

Contributed Abstract Type:

Paper

Participants:

Adriana Perez (1), Sarah Valencia (2), Pushan P Jani (3), Melissa B Harrell (4)

Institutions:

(1) The University of Texas Health Science Center at Houston, Austin, TX, (2) Michael & Susan Dell Center for Healthy Living. University of Texas Health Science Center Houston, Houston, TX, (3) The University of Texas Health Science Center at Houston, School of Medicine, Houston, TX, (4) The University of Texas Health Science Center at Houston, School of Public Health, Austin, TX

Co-Author(s):

Sarah Valencia
Michael & Susan Dell Center for Healthy Living. University of Texas Health Science Center Houston

Pushan P Jani
The University of Texas Health Science Center at Houston, School of Medicine

Melissa B Harrell
The University of Texas Health Science Center at Houston, School of Public Health

First Author:

Adriana Perez
The University of Texas Health Science Center at Houston

Presenting Author:

Adriana Perez
University of Texas At Houston, Health Science Center

Abstract Text:

Nicotine inhaled after 1-hour hookah session is higher than nicotine in a pack of cigarettes. The Population Assessment of Tobacco and Health (PATH) Study is a national longitudinal study of tobacco use and how it affects the health of people in the United States (2013-2021). PATH implemented a complex design that requires base and 100 balance repeated replicate weights to obtain variance estimates. Weighted interval-censoring survival analysis was used to estimate effect of hookah use on the age of asthma onset using the first wave of PATH participation sampling weights with a Fay correction factor of 0.3. Lower and upper age bounds were estimated. The effect of hookah use on the age of asthma onset was estimated using weighted interval-censoring-Cox regression with cubic splines (3 knots) as the baseline hazard function. Adults (≥18 years old) who reported an average length of hookah session of more than 30 minutes had a 352% increase risk in the onset of asthma at earlier ages in comparison to never or <30 minutes hookah users (HR: 4.52, 95%CI: 1.61-12.67). Attendees will learn how to implement interval-censoring survival analysis with balance repeated replicate weights.

Keywords:

Sponsors:

Survey Research Methods Section

Tracks:

Weighting/Variance Estimation

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