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Analysis of spatially clustered survival data with unobserved covariates using SBART

Abstract Number:

3601 

Submission Type:

Contributed Abstract 

Contributed Abstract Type:

Paper 

Participants:

Durbadal Ghosh (1), Debajyoti Sinha (2), Antonio Linero (1)

Institutions:

(1) N/A, N/A, (2) Florida State University, N/A

Co-Author(s):

Debajyoti Sinha  
Florida State University
Antonio Linero  
N/A

First Author:

Durbadal Ghosh  
N/A

Presenting Author:

Durbadal Ghosh  
N/A

Abstract Text:

Popular regression methods for clustered survival data become inadequate when functional forms of covariates and interactions are unknown. Spatially correlated random cluster effects and unknown cluster-level covariates further complicate the issue. In this context, we propose a nonparametric approach, SBART (soft Bayesian additive regression trees) within the Bayesian ensemble learning paradigm (Basak et al., 2022). Our method addresses challenges like numerous clusters, variable cluster sizes, and data information for proper statistical augmentation of the unobserved covariate sourced from a data registry different from the survival study. We illustrate the practical implementation of our method and its advantages over existing methods by assessing the impacts of intervention in some county level and patient-level covariates to eliminate existing racial disparity in breast cancer survival in different Florida counties. The sources of clustered survival data with patient-level covariates and the data information for an unobserved county-level covariate are different. We also compare our method with existing analysis methods to demonstrate our advantages through simulation studies.

Keywords:

Soft Bayesian Additive Regression Trees (SBART)|Data Augmentation|Disparity|Markov Chain Monte Carlo (MCMC)|Metropolis Hastings (MH) Algorithm. | Unobserved covariate

Sponsors:

Section on Nonparametric Statistics

Tracks:

Bayesian nonparametrics

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