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Impact of Immortal Time Bias in Mortality of Colorectal Cancer patients using Taiwan Cancer Registry

Abstract Number:

3632 

Submission Type:

Contributed Abstract 

Contributed Abstract Type:

Poster 

Participants:

Chung-Han Ho (1), Ching-Chieh Yang (2), Hsuan-Yi Huang (2), Zhi-Hao Wang (3), Yu-Cih Wu (2)

Institutions:

(1) Chi Mei Medical Center; Southern Taiwan University of Science and Technology, Tainan, Taiwan, (2) Chi Mei Medical Center, Tainan, Taiwan, (3) Southern Taiwan University of Science and Technology, Tainan, Taiwan

Co-Author(s):

Ching-Chieh Yang  
Chi Mei Medical Center
Hsuan-Yi Huang  
Chi Mei Medical Center
Zhi-Hao Wang  
Southern Taiwan University of Science and Technology
Yu-Cih Wu  
Chi Mei Medical Center

First Author:

Chung-Han Ho  
Chi Mei Medical Center; Southern Taiwan University of Science and Technology

Presenting Author:

Chung-Han Ho  
Chi Mei Medical Center

Abstract Text:

Introduction
Colorectal cancer (CRC) had higher cancer-related mortality. Due to the time bias between the cancer diagnosis and initial treatment date, the decreasing mortality after a patient receiving treatment may be exaggerated. This study aimed to explore the impact of immortal time bias on the mortality risk of CRC patients for improving the accuracy of risk prediction post-cancer diagnosis using the real-world databases, Taiwan Cancer Registry.
Methods
This study establishes a mortality risk model for CRC patients from 2012 to 2023. For assessing the immortal time bias of the mortality risk, Cox regression with landmark analysis and time-varying analysis approaches were used to estimate the hazard ratios with 95% confidence intervals.
Results and Conclusion
The time interval between diagnosis and treatment could be estimated using landmark and time-varying analysis approaches for accuracy of mortality prediction. The results indicated the correct design of methodology could elevate the precision of cancer mortality. In conclusion, exploring correlations over the time since diagnosis provides a more comprehensive perspective for improving CRC diagnosis and treatment.

Keywords:

Immortal Time Bias|Colorectal Cancer|Taiwan Cancer Registry|Cancer Mortality | |

Sponsors:

Section on Statistics in Epidemiology

Tracks:

Miscellaneous

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I understand that JSM participants must register and pay the appropriate registration fee by June 1, 2024. The registration fee is non-refundable.

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