Implementing weighted interval censoring survival analysis on tobacco regulatory science

Oregon Convention Center 

Nicotine inhaled after 1-hour hookah session is higher than nicotine in a pack of cigarettes. The Population Assessment of Tobacco and Health (PATH) Study is a national longitudinal study of tobacco use and how it affects the health of people in the United States (2013-2021). PATH implemented a complex design that requires base and 100 balance repeated replicate weights to obtain variance estimates. Weighted interval-censoring survival analysis was used to estimate effect of hookah use on the age of asthma onset using the first wave of PATH participation sampling weights with a Fay correction factor of 0.3. Lower and upper age bounds were estimated. The effect of hookah use on the age of asthma onset was estimated using weighted interval-censoring-Cox regression with cubic splines (3 knots) as the baseline hazard function. Adults (≥18 years old) who reported an average length of hookah session of more than 30 minutes had a 352% increase risk in the onset of asthma at earlier ages in comparison to never or <30 minutes hookah users (HR: 4.52, 95%CI: 1.61-12.67). Attendees will learn how to implement interval-censoring survival analysis with balance repeated replicate weights.

Interval Censoring Hazard Function

Balanced Repeated Replicate Weights

Sampling weights

Fay's variance estimation 

Survey Research Methods Section