ML10: The Major Research Directions for Nonlinear Dose-Response Modeling

David Farrar Presenting Author
 
Monday, Aug 5: 12:30 PM - 1:50 PM
3576 
Roundtables – Lunch 
Oregon Convention Center 
An effective dose in a health sciences context is a dose just large enough for a specified statistical effect on a response of interest (which may be beneficial or harmful). Effective doses inferred using nonlinear statistical models are subject to familiar types of modeling, inference, and numerical issues, including clustering, regularization, separated data, and parameter inequality constraints. The discussion will be initiated with a limited discussion related to chemical or microbial safety assessment; insights related to that and other domains of application will be welcomed.

Keywords

effective dose

nonlinear model

dose-response model

constrained inference 

Abstracts


Main Sponsor

Section on Teaching of Statistics in the Health Sciences