Implementation of Nonlinear Z-score Analysis for Cognitive Abnormality Detection

Abstract Number:

1800 

Submission Type:

Contributed Abstract 

Contributed Abstract Type:

Poster 

Participants:

Peijun Liu (1), John Kornak (2), Adam Staffaroni (1), Julie Fields (3), Jingxuan Wang (4), Elena Tsoy (5)

Institutions:

(1) University of California San Francisco, N/A, (2) University of California-San Francisco, N/A, (3) Mayo Clinic, MN, (4) University of California, San Francisco, MA, (5) University of California, San Francisco, CA

Co-Author(s):

John Kornak  
University of California-San Francisco
Adam Staffaroni  
University of California San Francisco
Julie Fields  
Mayo Clinic
Jingxuan Wang  
University of California, San Francisco
Elena Tsoy  
University of California, San Francisco

First Author:

Peijun Liu  
University of California San Francisco

Presenting Author:

Peijun Liu  
University of California San Francisco

Abstract Text:

Traditional linear methods for generating age, sex, and education level corrected Z-scores in neuropsychological assessments can be problematic because of nonlinearity and bounded test scores. We propose a nonlinear censored regression model for generating Z-scores that adjusts for age, sex, education, and race, while incorporating age-varying residual standard deviations. This approach addresses non-normal score distributions and boundary censoring, enhancing the detection of abnormal cognitive performance. Application to diverse normative datasets demonstrates improved accuracy and sensitivity over traditional methods, as corroborated by clinician feedback. Our results advocate for adopting this model to refine neuropsychological evaluations across varied populations.

Keywords:

Neuropsychological Testing
|Z-Score Adjustment|Censored Regression|Nonlinear Modeling|Cognitive Assessment|

Sponsors:

Mental Health Statistics Section

Tracks:

Big data/machine learning

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