Frequency Band Analysis of Multiple Stationary Time Series

Music City Center 

The frequency domain properties of biomedical signals offer valuable insights into health and functioning of underlying physiological systems. The power spectrum, which characterizes these properties, is often summarized by partitioning frequencies into standard bands and averaging power within bands. These summary measures are regularly used for analysis, but are not guaranteed to optimally retain differences in power spectra across signals from different participants. We propose a data-adaptive method for identifying frequency band summary measures that preserve spectral variability within a population of interest. The method can also identify subpopulations with distinct power spectra and summary measures that best characterize local dynamics. Validation criteria are developed to select a reasonable number of bands and subpopulations. An evolutionary algorithm is designed to simultaneously identify subpopulations and their corresponding summary measures. The method is used to analyze stride interval series from patients with different neurological disorders, revealing distinct subpopulations and the need for subpopulation-dependent summary measures.

Spectral analysis

Cluster validation

Evolutionary algorithm

Multitaper estimation

Gait variability

Stride interval 

ENAR