Estimation of Restricted Mean Time in Favor of Treatment: A Novel Method for Multi-State Models

Music City Center 

This paper introduces a novel method for estimating the restricted mean time in favor of treatment (RTM-IF), a metric extensively used in survival and recurrent event analyses. The RTM-IF measures the treatment effect on composite endpoints, such as survival or recurrent clinical events. Here, we propose a new method for estimating RTM-IF and compare it with classical methods. We further investigate the asymptotic distribution of the estimator. Through simulations and real-world data, we demonstrate the utility and applicability of the proposed method in complex clinical scenarios.

Clinical trials

composite endpoints

estimands

recurrent events

restricted mean survival time 

Biopharmaceutical Section