Testing interaction effects with weighted interval-censoring Cox proportional hazard models

Music City Center 

The Population Assessment of Tobacco and Health (PATH) Study is a national longitudinal study of tobacco use (2013-2021) that requires balanced repeated replicate weights for analysis. Crude and multivariable weighted interval-censoring Cox proportional hazard models were used to estimate two interaction effects (1) sex and years since first hookah use, and (2) ethnicity and years since first hookah use on the age of asthma onset. After controlling for covariates, women, Hispanics and non-Hispanic black adults who reported one or more years since first hookah use had increased risks of asthma onset at earlier ages in comparison to men and non-Hispanic white adults who reported never hookah use (HR= 4.93; 95% CI 2.10-11.58; HR= 5.18; 95% CI 2.21-12.16 and HR=1.63; 95% CI 1.09-2.43, respectively). Also, the interaction of sex and race/ethnicity with past 30-day(P30D) electronic cigarettes (ENDS) use on the age of asthma was estimated. Disseminating the results among health providers and the public about the interaction effect of sex and race/ethnicity with years since the first hookah or P30D ENDS use on earlier ages of asthma onset may encourage users to stop.

Sampling weights

Fay's variance estimation

Balanced Repeated Replicate Weights

Interval-Censoring Hazard Function

hazard risk

age of onset 

Survey Research Methods Section