Matching-Adjusted Indirect Comparison for Time-to-Event Endpoints

Music City Center 

To support Health Teachnology Assessment (HTA) submission, we often need to conduct indirect treatment comparisons (ITC). One of the most popular ITC methods is the Matching-Adjusted Indirect Comparison (MAIC), where the individual patient data (IPD) in one trial and the aggregate data (AgD) in another trial are compared for certain endpoints of interest adjusting for between-trial differences in the covariate distribution that influence outcome. In this abstract, we propose a unified approach using pseudo-value for MAIC with time-to-event (TTE) endpoints with MAIC, including survival rate, restricted mean survival time, and competing risks.

competing risks

HTA

MAIC

restricted mean survival time

time-to-event 

Biopharmaceutical Section