Fri, 11/8: 4:45 PM - 5:00 PM
Revolutionary artificial intelligence (AI)-based systems are transforming cytopathology practice. The Hologic Genius Digital Diagnostic System (GDDS) combines AI algorithmic analysis with volumetric imaging technology in the interpretation of ThinPrep Pap slides. Our study determines the sensitivity of HSIL interpretation by the GDDS and evaluates interobserver variability amongst cytopathologists.
A validation study was performed with 890 ThinPrep Paps where a cytotechnologist and three cytopathologists reviewed all of the cases on GDDS independently. A total of 183 cases originally interpreted as HSIL with histologic diagnosis of CIN2+ lesions confirmed by biopsy were included in this study. Sensitivity for detecting HSIL by three cytopathologists was calculated. Kendall's W coefficient was applied to calculate consistency of their interpretations.
AI-assisted Pap screening has the potential to further change cytology practice. GDDS aids in interpreting HSIL in ThinPrep Pap tests with high sensitivity and strong agreement between pathologists who interacted with this system. The variation in classification could be due to non-availability of clinical history, HPV status and learning involved during diagnosis. Additional studies focusing on workflow, AI-assisted diagnoses for all categories of The Bethesda System and outcomes are needed as more labs adopt the GDDS.
Most of the HSIL cases were classified as AGC/ASC-H and above by all cytopathologists. 11.5% of the cases were classified as LSIL by Pathologist A (PA), 6% by Pathologist B (PB) and 5.5 % by Pathologist C (PC). 3.8%, 2.7% and 1.6% cases were classified as ASCUS by PA, PB and PC respectively (Table 1). The sensitivity for detection of CIN2+ lesion was 100% if ASCUS and above lesions were counted amongst all three pathologists. The sensitivity for detection of CIN2+ lesions was 84.7%, 91.3%, and 92.9% by PA, PB and PC respectively, for ASC-H and above lesions (Table 2). Kendall's W coefficient was 0.722, indicating strong agreement between all pathologists.
Co-Presenter(s)
Esther Elishaev, MD, University of Pittsburgh School of Medine and UPMC
Yuhong Ye, MD, PhD, Department of Pathology, the first affiliated Hospital, Fujian Medical University
Jonee Matsko, SCT, MB(ASCP), UPMC Magee Womens Hospital
Amy Colaizzi, SCT, UPMC Magee Women's Hospital
Stephanie Wharton, BS, SCT (ASCP), UPMC Magee Women's Hospital
Liron Pantanowitz, MD, PhD, MHA, UPMCPitt
Chengquan Zhao, MD, Magee Womens Hospital of UPMC
Presenter
Lakshmi Harinath, MD MPH, UPMC
Presentation Category
Special Techniques (Includes Digital Cytology, AI + Information Technology)