Wed, 10/18: 1:30 PM - 2:30 PM EDT
Westin Boston Seaport
Room: Harbor Ballroom
To meet the goals of the European Union's chemical sustainability strategy, a larger array of chemicals will need to be evaluated as potential endocrine disruptors (ED)—that is, chemicals that may produce harmful effects in both humans and wildlife by interfering with hormone systems. The potential impact of ED evaluation on product value chains could be substantial, especially as the EU looks to adopt a "one substance, one evaluation" approach. Current proposed regulatory frameworks in the EU for evaluating ED potential are resource intensive and involve in-depth assessment of large amounts of information related to ED activity and potential adversity.
This presentation will describe a tiered strategy informed by existing regulatory frameworks for screening and prioritizing chemical portfolios for ED activity. The first tier employs an organized procedure for querying a series of key data sources of ED activity, such as quantitative structure-activity relationships (QSAR) data and in vitro data, to provide an initial portfolio-wide screen for ED potential. The second tier identifies data gaps, potential testing needs, and preliminary priority assignments. All information is compiled using a heat map approach that allows for easy visualization and customization, depending on the objective of the assessment. The presentation will share example analyses using this strategy.
Upon completion, the participant will be able to:
- Develop strategies for compiling information relevant to the assessment of endocrine disruption.
- Organize information on potential endocrine activity to enable next-step evaluation actions.
Communication & Training
Certified Professional Product Steward Domain Alignment
Domain I: Assessment, Impact Analysis, & Risk Management
Interactivity and Engagement