W2: Key Product Stewardship Concepts – Toxicology
Covestro LLC
Pittsburgh, PA
United States of America
Mon, 10/14: 8:00 AM - 12:00 PM MDT
Workshop Half Day
Workshop Half Day
Grand Hyatt Denver
Room: Mt. Sopris A
CM Credit Hours: 4
Description
Toxicology is a foundational element of one of the product steward's core competencies—understanding and mitigating human health hazards. This workshop will present the principles of toxicology as they relate to product stewardship. It will start with a systems approach to toxicology to provide participants with an understanding of the mechanisms by which chemicals alter the structure, function, or capacity of normal cells, organs, and systems, resulting in some type of effect. From this foundation, the workshop will cover the practical details of toxicology tests and understanding the reported results. Finally, the instructors will discuss incorporating the results and observations from toxicology tests into human health risk assessments for ingredients and products.
The instructors' goal is for the participants of this workshop to understand the information and decisions that go into human health hazard determinations and classifications. This workshop will focus on the principles of toxicology and the collection and interpretation of toxicology data. This is a basic course with no prerequisites. However, the instructors recommended that participants have a basic understanding of vertebrate biology.
The instructors' goal is for the participants of this workshop to understand the information and decisions that go into human health hazard determinations and classifications. This workshop will focus on the principles of toxicology and the collection and interpretation of toxicology data. This is a basic course with no prerequisites. However, the instructors recommended that participants have a basic understanding of vertebrate biology.
Learning Objectives
Upon completion, the participant will be able to…
• List the key principles of toxicology.
• Interpret the results of toxicology tests.
• Apply the results of toxicology testing to hazard communication and human health risk assessments.
• List the key principles of toxicology.
• Interpret the results of toxicology tests.
• Apply the results of toxicology testing to hazard communication and human health risk assessments.
Course Outline
Principles of toxicology:
• Dose-response characteristics.
• Systems toxicology—liver, kidney, neurological, immunological, reproductive-developmental, and dermal.
• Absorption-distribution-metabolism-excretion (ADME).
Toxicology testing for threshold effects:
• Overview of acute, immune (sensitization), and reproductive tests for products or ingredients.
• Chemical testing methods and study designs developed by the Organization for Economic Cooperation and Development (OECD).
• Non-animal testing methods.
Toxicology testing for non-threshold effects:
• Overview of carcinogenicity—genotoxicity, multi-stage mechanisms, and latency.
• Two-year carcinogenicity studies—methods and interpretation.
Use of toxicology testing results for hazard communication and human health risk assessment:
• Lowest adverse effect levels, no adverse effect levels, and points of departure.
• Systemic and point of contact responses.
• Safety (uncertainty) factors and derivation of reference doses.
• Assigning hazard categories.
• Dose-response characteristics.
• Systems toxicology—liver, kidney, neurological, immunological, reproductive-developmental, and dermal.
• Absorption-distribution-metabolism-excretion (ADME).
Toxicology testing for threshold effects:
• Overview of acute, immune (sensitization), and reproductive tests for products or ingredients.
• Chemical testing methods and study designs developed by the Organization for Economic Cooperation and Development (OECD).
• Non-animal testing methods.
Toxicology testing for non-threshold effects:
• Overview of carcinogenicity—genotoxicity, multi-stage mechanisms, and latency.
• Two-year carcinogenicity studies—methods and interpretation.
Use of toxicology testing results for hazard communication and human health risk assessment:
• Lowest adverse effect levels, no adverse effect levels, and points of departure.
• Systemic and point of contact responses.
• Safety (uncertainty) factors and derivation of reference doses.
• Assigning hazard categories.
Risk Assessments
Existing Chemical Risk Assessments - General
Certified Professional Product Steward Domain Alignment
Domain I: Assessment, Impact Analysis, & Risk Management
Content Level
Introductory
Interactivity and Engagement
Q&A
Quiz
Transfer of Knowledge
Practice exercises