W2: Key Product Stewardship Concepts – Toxicology

Dr. Robert Skoglund, PhD, DABT, CIH, CPPS Lead Instructor
Covestro LLC
Pittsburgh, PA 
United States of America
Bob DeMott, PhD DABT Instructor
Tampa, FL 
United States of America
Mon, 10/14: 8:00 AM - 12:00 PM MDT
Workshop Half Day 
Grand Hyatt Denver 
Room: Mt. Sopris A 
CM Credit Hours:


Toxicology is a foundational element of one of the product steward's core competencies—understanding and mitigating human health hazards. This workshop will present the principles of toxicology as they relate to product stewardship. It will start with a systems approach to toxicology to provide participants with an understanding of the mechanisms by which chemicals alter the structure, function, or capacity of normal cells, organs, and systems, resulting in some type of effect. From this foundation, the workshop will cover the practical details of toxicology tests and understanding the reported results. Finally, the instructors will discuss incorporating the results and observations from toxicology tests into human health risk assessments for ingredients and products.

The instructors' goal is for the participants of this workshop to understand the information and decisions that go into human health hazard determinations and classifications. This workshop will focus on the principles of toxicology and the collection and interpretation of toxicology data. This is a basic course with no prerequisites. However, the instructors recommended that participants have a basic understanding of vertebrate biology.

Learning Objectives

Upon completion, the participant will be able to…
• List the key principles of toxicology.
• Interpret the results of toxicology tests.
• Apply the results of toxicology testing to hazard communication and human health risk assessments.

Course Outline

Principles of toxicology:
• Dose-response characteristics.
• Systems toxicology—liver, kidney, neurological, immunological, reproductive-developmental, and dermal.
• Absorption-distribution-metabolism-excretion (ADME).
Toxicology testing for threshold effects:
• Overview of acute, immune (sensitization), and reproductive tests for products or ingredients.
• Chemical testing methods and study designs developed by the Organization for Economic Cooperation and Development (OECD).
• Non-animal testing methods.
Toxicology testing for non-threshold effects:
• Overview of carcinogenicity—genotoxicity, multi-stage mechanisms, and latency.
• Two-year carcinogenicity studies—methods and interpretation.
Use of toxicology testing results for hazard communication and human health risk assessment:
• Lowest adverse effect levels, no adverse effect levels, and points of departure.
• Systemic and point of contact responses.
• Safety (uncertainty) factors and derivation of reference doses.
• Assigning hazard categories.

Risk Assessments

Existing Chemical Risk Assessments - General

Certified Professional Product Steward Domain Alignment

Domain I: Assessment, Impact Analysis, & Risk Management

Content Level


Interactivity and Engagement


Transfer of Knowledge

Practice exercises