W3: Toxicology Principles - A Deeper Dive
Solutions in Science, LLC
Bainbridge Island, WA
United States of America
Mon, 10/14: 1:00 PM - 5:00 PM MDT
Workshop Half Day
Workshop Half Day
Grand Hyatt Denver
Room: Maroon Peak
CM Credit Hours: 4
Description
An understanding of toxicology is paramount to a product steward, given their potential responsibility for the effects of unsafe products on human health and the environment.
This half-day workshop will review toxicology basics and then dive deeper into toxicological principles essential to product stewardship. The instructors will use a mixture of lectures, discussions, polls, and quizzes to discuss the absorption, distribution, metabolism, and excretion of toxicants—that is, toxicokinetics. They will also cover the effects of toxicants on major organs; toxicant classifications such as carcinogens and persistent, bioaccumulative, and toxic chemicals (PBT); and endocrine disrupters. The instructors will explain how exposure limits and toxicity reference values are derived using experimental doses, uncertainty and modifying factors for use in product risk assessment, and how qualitative and quantitative structural activity relationships (QSARS) are applied when empirical data are not available.
The course will include a section on ecotoxicology and its relevancy to product stewardship. This will take the form of a discussion on how exposure can cause adverse effects from individuals up through the food chain via trophic transfer.
The instructors will also request examples of toxicological issues confronting product stewards from students for discussion during the workshop.
This half-day workshop will review toxicology basics and then dive deeper into toxicological principles essential to product stewardship. The instructors will use a mixture of lectures, discussions, polls, and quizzes to discuss the absorption, distribution, metabolism, and excretion of toxicants—that is, toxicokinetics. They will also cover the effects of toxicants on major organs; toxicant classifications such as carcinogens and persistent, bioaccumulative, and toxic chemicals (PBT); and endocrine disrupters. The instructors will explain how exposure limits and toxicity reference values are derived using experimental doses, uncertainty and modifying factors for use in product risk assessment, and how qualitative and quantitative structural activity relationships (QSARS) are applied when empirical data are not available.
The course will include a section on ecotoxicology and its relevancy to product stewardship. This will take the form of a discussion on how exposure can cause adverse effects from individuals up through the food chain via trophic transfer.
The instructors will also request examples of toxicological issues confronting product stewards from students for discussion during the workshop.
Learning Objectives
Upon completion, the participant will be able to…
• Review toxicological principles.
• Discuss the major types of toxicological interactions between and among toxicant exposures.
• Explain the process by which toxicants enter organisms, are distributed and metabolized, and then excreted (toxicokinetics).
• Explain the human health and ecological risk assessment process and provide necessary resources.
• Recognize various computer-based models used in toxicology that estimate toxicokinetics (such as physiologically-based pharmacokinetic or PBPK) or adverse health effects (such as in silico and QSAR).
• Develop exposure limits for human health and toxicity reference values (TRVs) for ecological risk, using no observed adverse effect levels (NOAELs) or lowest observe adverse effect levels (LOAELs) and uncertainty factors.
• Identify the ecotoxicological effects of toxicants throughout the food chain via trophic transfer.
• Identify current toxicological issues in product stewardship.
• Review toxicological principles.
• Discuss the major types of toxicological interactions between and among toxicant exposures.
• Explain the process by which toxicants enter organisms, are distributed and metabolized, and then excreted (toxicokinetics).
• Explain the human health and ecological risk assessment process and provide necessary resources.
• Recognize various computer-based models used in toxicology that estimate toxicokinetics (such as physiologically-based pharmacokinetic or PBPK) or adverse health effects (such as in silico and QSAR).
• Develop exposure limits for human health and toxicity reference values (TRVs) for ecological risk, using no observed adverse effect levels (NOAELs) or lowest observe adverse effect levels (LOAELs) and uncertainty factors.
• Identify the ecotoxicological effects of toxicants throughout the food chain via trophic transfer.
• Identify current toxicological issues in product stewardship.
Course Outline
• Toxicology principles
• Toxicology terminology
• Toxicokinetics (adsorption, distribution, metabolism, and excretion)
• Target organ toxicity
• Toxicant classification systems (carcinogens and PBTs)
• Toxicological issues in product stewardship (PBTs and endocrine disrupters)
• Ecological issues in product stewardship (terminology and trophic transfer)
• Exposure limits and TRVs
• Qualitative/quantitative structural activity relationships (QSARs)
• Current toxicological issues in product stewardship
• Toxicology terminology
• Toxicokinetics (adsorption, distribution, metabolism, and excretion)
• Target organ toxicity
• Toxicant classification systems (carcinogens and PBTs)
• Toxicological issues in product stewardship (PBTs and endocrine disrupters)
• Ecological issues in product stewardship (terminology and trophic transfer)
• Exposure limits and TRVs
• Qualitative/quantitative structural activity relationships (QSARs)
• Current toxicological issues in product stewardship
Risk Assessments
Exposure Considerations based on chemical use
Certified Professional Product Steward Domain Alignment
Domain I: Assessment, Impact Analysis, & Risk Management
Content Level
Intermediate
Interactivity and Engagement
Polling
Q&A
Quiz
Small Group Discussion
Transfer of Knowledge
Group activities
Interactive games
Practice exercises