WS1: Key Product Stewardship Concepts — Toxicology

Westin Galleria Houston 

CM Credit Hours: 3.5 

A core competency of product stewardship is understanding and mitigating human health hazards. Toxicology is a foundational element of this competency. This workshop will present the principles of toxicology as they relate to product stewardship.

The workshop will begin with a systems approach to toxicology to provide participants with an understanding of the mechanisms by which chemicals alter the structure, function, or capacity of normal cells, organs, and systems. Building from this foundation, the workshop will guide participants towards understanding the practical details of toxicology tests and the reported results. Finally, the workshop will discuss incorporating results and observations from these tests into human health risk assessment for ingredients and products. The goal is for participants to understand the information and decisions that go into human health hazard determinations and classifications.

This course will focus on the principles of toxicology and the collection and interpretation of toxicology data. This will be a basic course with no prerequisites. However, it is recommended that participants have a basic understanding of vertebrate biology.

Upon completion, the participant will be able to:

• Recall key principles of toxicology.
• Explain the results of toxicology testing.
• Apply the results of toxicology testing to hazard communication and human health risk assessments.
 

Principles of toxicology:
• Dose-response characteristics
• Systems toxicology, including liver, kidney, neurological, immunological, reproductive-developmental, and dermal toxicology
• Absorption, distribution, metabolism, and excretion (ADME)

Toxicology testing for threshold effects:
• Acute, immune (sensitization), and reproductive testing for products and ingredients
• Organization for Economic Co-operation and Development (OECD) test methods and study designs
• Non-animal testing

Toxicology testing for non-threshold effects:
• Carcinogenicity, including genotoxicity, multi-stage mechanisms, and latency
• Methods and interpretation of two-year carcinogenicity studies

Use of toxicology findings for hazard communication and human health risk assessment:
• Lowest adverse effect levels, no adverse effect levels, and points of departure
• Systemic versus point of contact responses
• Safety (uncertainty) factors and derivation of reference doses
• Hazard categories
 

Chemical Risk Assessments - General

Domain I: Assessment, Impact Analysis, & Risk Management

Q&A

Quiz

Practice exercises

Introductory