WS1: Key Product Stewardship Concepts — Toxicology

Westin Galleria Houston 

CM Credit Hours: 3.5 

A core competency of stewardship is the understanding and mitigating of human health hazards, and toxicology is a foundational element of this competency. This workshop presents the principles of toxicology as they relate to product stewardship. The workshop starts with a systems approach to toxicology in order to provide participants with an understanding of the mechanisms by which chemicals alter structure, function, or capacity of normal cells, organs, and system, resulting in some type of effect. From this foundation, the workshop moves to the practical details of understanding toxicology tests and the reported results. The final building block will be discussing how to incorporate the results and observations from such tests in human health risk assessment for ingredients and products. The goal is for participants to understand the information and decisions that go into human health hazard determinations and classifications. This course will focus on the principles of toxicology and the collection and interpretation of toxicology data. This is a basic course and there are no prerequisites. However, it is recommended that participants have a basic understanding of vertebrate biology.

1) Remembering key principles of toxicology
2) Understanding the results of toxicology testing
3) Applying the results of toxicology testing to hazard communication and human health risk assessments

 

1) Principles of toxicology
• Dose-response characteristics
• Systems toxicology – liver, kidney, neurological, immunological, reproductive-developmental, dermal
• Absorption-Distribution-Metabolism-Excretion (ADME)

2) Toxicology testing for threshold effects
• Overview of acute, immune (sensitization), reproductive tests for products/ingredients
• OECD test methods and study designs
• Non-animal tests

3) Toxicology testing for non-threshold effects
• Overview of carcinogenicity – genotoxicity, multi-stage mechanisms, latency
• Two-year carcinogenicity studies – methods and interpretation

4) Use of toxicology findings for hazard communication and human health risk assessment
• Recognizing lowest adverse effect and no adverse effect levels and Points of Departure
• Differentiating systemic from point of contact responses
• Safety (Uncertainty) Factors and derivation of Reference Doses
• Assigning hazard categories 

Chemical Risk Assessments - General

Domain I: Assessment, Impact Analysis, & Risk Management

Q&A

Quiz

Practice exercises

Introductory