08 Bethanechol's Impact on Pulmonary Severity: A Longitudinal Case Control Study

Oregon Convention Center 

This poster details a retrospective cohort study conducted at a single center, analyzing 33 patients (11 receiving Bethanechol treatment, 22 controls) hospitalized from 2017 to 2022. The study examines the effect of Bethanechol on individuals with Tracheobronchomalacia (TBM) and bronchopulmonary dysplasia. A case-control match (1:2 ratio) factored in gestational age, sex, TBM and bronchopulmonary dysplasia severity, and respiratory support. The primary focus was Bethanechol's impact on the Pulmonary Severity Score. Unique to this study, Bethanechol administration dates varied over a 105-day period for each case. The poster will display various statistical approaches used to navigate the study's complexities, with a particular emphasis on advanced visualization techniques that clarify the treatment's time-dependent effects. A comparison and discussion of different statistical methods will also be featured.

case control

mixed model

longitudinal

data visualization

clinical study

dependent 

Biometrics Section